This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
MA5-15449 targets SOX2 in WB applications and shows reactivity with Human samples.
The MA5-15449 immunogen is purified recombinant fragment of SOX2 (aa1-170) expressed in E. Coli.
MA5-15449 detects SOX2 which has a predicted molecular weight of approximately 34.3kDa.
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
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Protein Aliases: sex determining region Y-box 2; SOX 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2
Gene Aliases: ANOP3; MCOPS3; SOX2
UniProt ID: (Human) P48431
Entrez Gene ID: (Human) 6657
Molecular Function: HMG box transcription factor