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      View (20) other SOX2 antibodies

      Invitrogen

      SOX2 Monoclonal Antibody (20G5)

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      Antibody target was verified by Cell Treatment to ensure the antibody binds to the antigen stated. View details.

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      Catalog #:MA1-014

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      Product Details

      TESTED APPLICATIONS DILUTION
      ChIP assay (ChIP) 1-3 ul
      Flow Cytometry (Flow) 1:100
      Immunocytochemistry (ICC) 1:200
      Immunofluorescence (IF) 1:200
      Immunohistochemistry (Paraffin) (IHC (P)) 1:20-1:200
      Immunoprecipitation (IP) 5 µg
      Western Blot (WB) 1:1000 - 1:2000
      PUBLISHED APPLICATIONS
      Miscellaneous PubMed (MISC) See 1 publications below
      Immunohistochemistry (IHC) See 1 publications below
      Western Blot (WB) See 1 publications below
      Tested Species reactivity Dog, Fish, Human, Mouse
      Published species reactivity Human
      Host / Isotype Mouse / IgG1, kappa
      Class Monoclonal
      Type Antibody
      Clone 20G5
      Immunogen Full-length human recombinant protein expressed in bacteria
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Protein A
      Storage buffer PBS with 30% glycerol, 1mg/ml BSA
      Contains 0.05% sodium azide
      Storage conditions -20°C
      RRID AB_2536667

      Product Specific Information

      Western blot analysis of MA1-014 specifically detects SOX2 protein at ~36 kDa in the nucleus of human and mouse embryonal carcinoma and iPS cells.

      Background/Target Information

      This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (3)

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      Bioinformatics

      Protein Aliases: ANOP3; MCOPS3; sex determining region Y box 2; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

      Gene Aliases: ANOP3; lcc; MCOPS3; Sox-2; SOX2; ysb

      UniProt ID: (Human) P48431, (Mouse) P48432

      Entrez Gene ID: (Human) 6657, (Dog) 488092, (Mouse) 20674

      Molecular Function: HMG box transcription factor nucleic acid binding transcription factor

      Function(s) Blue Arrow Icon
      negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis
      Process(es) Blue Arrow Icon
      transcription regulatory region sequence-specific DNA binding
       transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
       DNA binding
       transcription factor activity, sequence-specific DNA binding
       protein binding
       miRNA binding
       sequence-specific DNA binding
       transcription regulatory region DNA binding
       RNA polymerase II transcription factor activity, sequence-specific DNA binding
       chromatin binding
       transcription factor binding
       chromatin DNA binding
       protein heterodimerization activity

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