MA5-17177 targets SOX9 in indirect ELISA, ICC, IF and WB applications and shows reactivity with Human samples.
The MA5-17177 immunogen is purified recombinant fragment of human SOX9 expressed in E. Coli.
MA5-17177 detects SOX9 which has a predicted molecular weight of approximately 56kDa.
SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SOX 9; SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-Box 9 ; SRY-related HMG-box, gene 9; Transcription factor SOX-9
Gene Aliases: CMD1; CMPD1; SOX9; SRA1; SRXX2; SRXY10
UniProt ID: (Human) P48436
Entrez Gene ID: (Human) 6662