|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminal region of human SP3/4|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010].
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Protein Aliases: DKFZp686O1631; GC-binding transcription factor Sp3; HF-1b zinc finger protein; specificity protein 3; SPR-1; SPR-2; SPR1; SPR2; trans-acting transcription factor 3; trans-acting transcription factor 4; Transcription factor Sp3; Transcription factor Sp4
Gene Aliases: 5730497N03Rik; D130027J01Rik; HF-1b; HF1-b; HF1B; SP3; SP4; SPR-1; SPR2
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