Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:100 | - |
Flow Cytometry (Flow) |
1:100 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI1C12 |
Immunogen |
Human recombinant protein fragment corresponding to amino acids 300-573 of human SPG7 prodduced in E.coli. |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.86 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cell adhesion regulator; Cell matrix adhesion regulator; Paraplegin; paraplegin, isoform 1; spastic paraplegia 7 (pure and complicated autosomal recessive); Spastic paraplegia 7 protein
Gene Aliases: AI452278; AU015315; CAR; CMAR; PGN; SPG5C; SPG7
UniProt ID: (Human) Q9UQ90, (Mouse) Q3ULF4
Entrez Gene ID: (Human) 6687, (Mouse) 234847
Molecular Function:
metalloprotease
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