Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.
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Protein Aliases: 1 (antagonist of FGF signaling); antagonist of FGF signaling (Drosophila); Drosophila; homolog of; hSPRY1; Protein sprouty homolog 1; sprouty; sprouty (Drosophila) homolog 1 (antagonist of FGF signaling); sprouty homolog 1; Spry-1; SPRY1
Gene Aliases: sprouty1; spry-1; Spry1
UniProt ID: (Mouse) Q9QXV9
Entrez Gene ID: (Mouse) 24063