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SPTAN1/Alpha II-spectrin Antibody (A301-248A) in IHC
Detection of human SPTAN1/Alpha II-Spectrin by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti- SPTAN1/Alpha II-Spectrin (Cat. No. A301-248A Lot2) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB.
Product Details
A301-248A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1000 and 1050 of Human spectrin, alpha, non-erythrocytic 1.
Conjugate
Unconjugated
Form
liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Chicken
Target Information
SPTAN1 (spectrin alpha chain, non-erythrocytic 1) is a part of the spectrin family of filamentous cytoskeletal proteins. They function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (ALPHA)II-SPECTRIN; alpha; alpha-fodrin; Alpha-II spectrin; alpha-spectrin 2, brain; brain; FLJ44613; Fodrin alpha chain; Non erythrocytic spectrin alpha; non-erythrocytic 1 (alpha-fodrin); non-erythroid alpha chain; Spectrin; Spectrin alpha; Spectrin alpha chain brain; spectrin alpha chain, brain; Spectrin alpha chain, non-erythrocytic 1; spectrin, non-erythroid alpha chain; Spectrin, non-erythroid alpha subunit
Gene Aliases: 2610027H02Rik; EIEE5; NEAS; Spna-2; Spna2; SPTA2; SPTAN1
UniProt ID: (Human) Q13813
Entrez Gene ID: (Human) 6709, (Mouse) 20740
actin binding
Ras guanyl-nucleotide exchange factor activity
structural constituent of cytoskeleton
calcium ion binding
protein binding
calmodulin binding
syntaxin binding
protein complex binding
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
spectrin binding
metal ion binding
protein heterodimerization activity
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