SR proteins are a highly conserved family of arginine/serine-rich, spliceosome-associated phosphoproteins essential for metazoan pre-mRNA splicing. SR proteins act early in splicing by promoting splice site recognition and spliceosome assembly. SR proteins also play a regulatory role because they can determine alternative splice site usage in vivo and in vitro. SR proteins appear to be recruited from nuclear “speckles”, in which they are concentrated to sites of transcription in order to spatially coordinate transcription and pre-mRNA splicing within the cell nucleus.
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Protein Aliases: Delayed-early protein HRS; epididymis secretory protein Li 91; Insulin-induced growth response protein CL-4; pre-mRNA splicing factor SRp20; Pre-mRNA-splicing factor SRP20; Pre-mRNA-splicing factor SRP40; Pre-mRNA-splicing factor SRP55; Pre-mRNA-splicing factor SRP75; Protein X16; Serine/arginine-rich splicing factor 3; Serine/arginine-rich splicing factor 4; Serine/arginine-rich splicing factor 5; Serine/arginine-rich splicing factor 6; splicing factor arginine/serine-rich 5 (SRp40 HRS); Splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich 3 (SRp20); Splicing factor, arginine/serine-rich 4; splicing factor, arginine/serine-rich 4 (SRp75); Splicing factor, arginine/serine-rich 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS); Splicing factor, arginine/serine-rich 6; splicing factor, arginine/serine-rich, 20-kD; splicing factor, arginine/serine-rich, 55 kDa; SR splicing factor 4; SR splicing factor 5; SR splicing factor 6; SRP001LB
Gene Aliases: 1210001E11Rik; 5730499P16Rik; AI314910; AL024116; AW146126; AW550192; B52; Cl-4; HEL-S-91; HRS; MNCb-2616; RGD1561347; SFRS3; SFRS4; SFRS5; SFRS6; SRP20; SRP40; SRP55; SRP75; SRSF3; SRSF4; SRSF5; SRSF6; X16
Molecular Function: RNA splicing factor