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SR Antibody (MA5-44854) in IHC (P)
Immunohistochemistry analysis of SR protein repeat in paraffin-embedded human breast carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with SR protein repeat Monoclonal antibody (Product # MA5-44854) using a di... View More
Product Details
MA5-44854
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE61-82
Immunogen
Synthetic peptide within human SR protein repeat aa 150-199/344.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2931310
Target Information
SR proteins are a highly conserved family of arginine/serine-rich, spliceosome-associated phosphoproteins essential for metazoan pre-mRNA splicing. SR proteins act early in splicing by promoting splice site recognition and spliceosome assembly. SR proteins also play a regulatory role because they can determine alternative splice site usage in vivo and in vitro. SR proteins appear to be recruited from nuclear “speckles”, in which they are concentrated to sites of transcription in order to spatially coordinate transcription and pre-mRNA splicing within the cell nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delayed-early protein HRS; epididymis secretory protein Li 91; Insulin-induced growth response protein CL-4; pre-mRNA splicing factor SRp20; Pre-mRNA-splicing factor SRP20; Pre-mRNA-splicing factor SRP40; Pre-mRNA-splicing factor SRP55; Pre-mRNA-splicing factor SRP75; Protein X16; Serine/arginine-rich splicing factor 3; Serine/arginine-rich splicing factor 4; Serine/arginine-rich splicing factor 5; Serine/arginine-rich splicing factor 6; splicing factor arginine/serine-rich 5 (SRp40 HRS); Splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich 3 (SRp20); Splicing factor, arginine/serine-rich 4; splicing factor, arginine/serine-rich 4 (SRp75); Splicing factor, arginine/serine-rich 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS); Splicing factor, arginine/serine-rich 6; splicing factor, arginine/serine-rich, 20-kD; splicing factor, arginine/serine-rich, 55 kDa; SR splicing factor 4; SR splicing factor 5; SR splicing factor 6; SRP001LB
Gene Aliases: 1210001E11Rik; 5730499P16Rik; AI314910; AL024116; AW146126; AW550192; B52; Cl-4; HEL-S-91; HRS; MNCb-2616; RGD1561347; SFRS3; SFRS4; SFRS5; SFRS6; SRP20; SRP40; SRP55; SRP75; SRSF3; SRSF4; SRSF5; SRSF6; X16
UniProt ID: (Human) P84103, (Human) Q08170, (Human) Q13243, (Human) Q13247, (Mouse) P84104, (Rat) Q09167, (Mouse) O35326, (Rat) G3V6S8, (Mouse) Q3TWW8
Entrez Gene ID: (Human) 6428, (Human) 6429, (Human) 6430, (Human) 6431, (Rat) 361814, (Mouse) 20383, (Rat) 362612, (Mouse) 57317, (Rat) 29667, (Mouse) 20384, (Rat) 362264, (Mouse) 67996
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
mRNA 3'-end processing
regulation of mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
mRNA processing
RNA splicing
negative regulation of mRNA splicing, via spliceosome
mRNA splice site selection
response to wounding
cellular response to insulin stimulus
regulation of cell cycle
liver regeneration
alternative mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome
regulation of keratinocyte proliferation
negative regulation of keratinocyte differentiation
positive regulation of epithelial cell proliferation involved in lung morphogenesis
negative regulation of cell death
regulation of wound healing
transport
insulin receptor signaling pathway
mRNA transport
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
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