Product is supplied at 1 mL (100 µL/mL).
Application Notes: Functional Assay- This antibody is useful for neutralization of the biological activity of SR-BI. For neutralization of biological activity dilutions have to be made according to the amounts SR-BI to be inactivated.
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; SCARB1; scavanger receptor class B type 1; Scavenger receptor class B member 1; Scavenger Receptor-B1; Scavenger Receptor-BI; SR-B1; SR-BI; SRB1
Gene Aliases: Cd36l1; Scarb1; SR-B1; Srb1
UniProt ID: (Rat) P97943
Entrez Gene ID: (Rat) 25073
Molecular Function: receptor