High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
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Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; Scavenger receptor class B member 1; scavenger receptor class B type III; scavenger receptor class B, member 1; SR-BI; SRB1
Gene Aliases: CD36L1; CLA-1; CLA1; HDLQTL6; SCARB1; SR-BI; SRB1
UniProt ID: (Human) Q8WTV0
Entrez Gene ID: (Human) 949
Molecular Function: receptor