|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Rat|
|Host / Isotype||Sheep / IgG|
|Immunogen||Recombinant protein corresponding to residues 620-1596 of SSeCKS.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is rat aortic smooth muscle lysate.
The Src family of protein tyrosine kinases are non-receptor kinases whose role is important in the regulation of growth and differentiation of eukaryotic cells (1,2). Activity of Src is regulated phosphorylation of two tyrosine residues (Tyr 416 and Tyr527). Phosphorylation of these two sites has opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity. It has been shown that the phosphorylation of Tyr527 decreases enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; SSeCKS, Gravin, AKAP250
Gene Aliases: Akap12; AKAP12A; AKAP12B; AKAP12G
UniProt ID: (Rat) Q5QD51
Entrez Gene ID: (Rat) 83425
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