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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Raised against amino acids 477-947 of SRC-1 fusion protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
|Western Blot (WB)||1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-90579 detects SRC1 from mouse, human samples.
MA1-90579 has been successfully used in immunofluorescence, immunohistochemistry (paraffin tissue), Western blot applications.
The MA1-90579 immunogen is: Raised against amino acids 477-947 of SRC-1 fusion protein
SRC 1 belongs to the SRC family, which includes TIF2 / GRIP 1, and RAC3/ ACTR/ pCIP/AIB1. Thee cofactors interact with nuclear receptors in a ligand dependent manner and enhance transcriptional activation by the receptor via histone acetylation / methylation and recruitment of additional cofactors such as CBP / p300.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.
MA1-90579 was used in immunoprecipitation to investigate the regulation of cyclin D1 expression in breast cancer cells
|Nakuci E,Mahner S,Direnzo J,ElShamy WM||Experimental cell research (312:3120)||2006|
The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.
MA1-90579 was used in western blot to investigate the effect of diethylhexyl phthalate on MDR1 gene expression
|Takeshita A,Inagaki K,Igarashi-Migitaka J,Ozawa Y,Koibuchi N||The Journal of endocrinology (190:897)||2006|
ASV; c-SRC; class E basic helix-loop-helix protein 74; Hin-2 protein; mNRC-1; NCoA-1; nuclear receptor coactivator 1; nuclear receptor coactivator protein 1; p60-Src; PAX3/NCOA1 fusion protein; renal carcinoma antigen NY-REN-52; SRC-a/NCoA-1; SRC1; steroid receptor coactivator 1; steroid receptor coactivator-1
bHLHe42; BHLHE74; F-SRC-1; KAT13A; NCOA1; RIP160; SRC-1; SRC1