MA5-11553 targets GRIP1 in IP and WB applications and shows reactivity with Human samples.
The MA5-11553 immunogen is recombinant human GRIP1 protein.
The steroid hormones, thyroid hormone, vitamin D, and retinoic acid function by activating specific "nuclear receptor proteins" found inside of target cells. The activated receptors bind to and activate specific genes, and the products of these activated genes change cellular activities in specific ways, thus constituting the biological response to the hormone. After binding to target genes, the activated nuclear receptors require the assistance of proteins called "transcriptional co-activators" in order to activate the target genes. GRIP1 (Glucocorticoid Receptor Interacting Protein 1) is a novel protein that serves as a transcriptional co-activator for steroid and nuclear hormone receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHe75; Class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1; glutamate receptor-interacting protein 1; hTIF2; NCoA-2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; Transcriptional intermediary factor 2
Gene Aliases: BHLHE75; GRIP1; KAT13C; NCoA-2; NCOA2; SRC2; TIF2
UniProt ID: (Human) Q15596
Entrez Gene ID: (Human) 10499