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Product Details
66329-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D5D8
Immunogen
SRD5A1 Fusion Protein Ag23351 (1-163 aa encoded by BC007033)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATATGVAE ERLLAALAYL QCAVGCAVFA RNRQTNSVYG RHALPSHRLR VPARAAWVVQ ELPSLALPLY QYASESAPRL RSAPNCILLA MFLVHYGHRC LIYPFLMRGG KPMPLLACTM AIMFCTCNGY LQSRYLSHCA VYADDWVTDP RFLIGFGLWL TGML (1-163 aa encoded by BC007033)
Target Information
Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Gene Aliases: S5AR 1; SRD5A1
UniProt ID: (Human) P18405
Entrez Gene ID: (Human) 6715
urogenital system development
liver development
steroid biosynthetic process
androgen biosynthetic process
sex determination
male gonad development
cellular response to starvation
response to muscle activity
diterpenoid metabolic process
spinal cord development
hippocampus development
thalamus development
hypothalamus development
pituitary gland development
cerebral cortex development
cell differentiation
male genitalia development
female genitalia development
response to follicle-stimulating hormone
cellular response to insulin stimulus
serotonin metabolic process
progesterone metabolic process
response to drug
circadian sleep/wake cycle, REM sleep
response to estrogen
oxidation-reduction process
bone development
response to growth hormone
response to fungicide
cellular response to cAMP
cellular response to growth factor stimulus
cellular response to estradiol stimulus
cellular response to testosterone stimulus
cellular response to dexamethasone stimulus
cellular response to epinephrine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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