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The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. SRM synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Protein Aliases: Putrescine aminopropyltransferase; SPDSY; Spermidine synthase; spermidine synthase-1
Gene Aliases: AA407669; PAPT; SpdST; SPDSY; SPS1; SRM; SRML1
Molecular Function: transferase