This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: alternative-splicing factor 1; arginine/serine-rich 1; ASF/SF2; P33 subunit; pre-mRNA-splicing factor SF2; pre-mRNA-splicing factor SF2, P33 subunit; pre-mRNA-splicing factor SRp30a; serine/arginine-rich splicing factor 1; SF2; SF2p33; SFRS1; splicing factor; splicing factor 2; splicing factor, arginine/serine-rich 1; splicing factor, arginine/serine-rich 1 (ASF/SF2); splicing factor, arginine/serine-rich 1B; splicing factor, arginine/serine-rich, 30-KD, A; SR splicing factor 1; SRp30a
Gene Aliases: 1110054N12Rik; 5730507C05Rik; 6330415C05Rik; AI482334; ASF; AW491331; SF2; SF2p33; SFRS1; SRp30a