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SSTR3 Antibody (MA5-44784) in IHC (P)
Immunohistochemistry analysis of SSTR3 in paraffin-embedded human small intestine tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with SSTR3 Monoclonal antibody (Product # MA5-44784) using a dilution of 1:400 for 1 hour at ... View More
Product Details
MA5-44784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE63-87
Immunogen
Synthetic peptide within human SSTR3 aa 369-418/418.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2931241
Target Information
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: somatostatin receptor; Somatostatin receptor type 3; SS-3-R; SSR-28
Gene Aliases: SS-3-R; SS3-R; SS3R; SSR-28; SSTR3
UniProt ID: (Human) P32745
Entrez Gene ID: (Human) 6753
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cell-cell signaling
chemical synaptic transmission
spermatogenesis
negative regulation of cell proliferation
hormone-mediated apoptotic signaling pathway
cerebellum development
forebrain development
somatostatin signaling pathway
response to starvation
cellular response to glucocorticoid stimulus
cellular response to estradiol stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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