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Product Details
H00006764-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1A3
Immunogen
ST5 (NP_005409, 1038 a.a. approximately 1135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: VGHYSLFLTQ SEKGERAFQR EAFRKSVASK SIRRFLEVFM ESQMFAGFIQ DRELRKCRAK GLFEQRVEQY LEELPDTEQS GMNKFLRGLG NKMKFLHK
Target Information
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DENN domain-containing protein 2B; DENN/MADD domain containing 2B; HeLa tumor suppression 1; Suppression of tumorigenicity 5 protein
Gene Aliases: DENND2B; HTS1; p126; ST5
UniProt ID: (Human) P78524
Entrez Gene ID: (Human) 6764
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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