This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.
Protein Aliases: 190 kDa form stabilin-2; 190 kDa hyaluronan receptor for endocytosis; CD44-like precursor FELL; DKFZP434E0321; FAS1 EGF-like and X-link domain containing adhesion molecule-2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; FELL-2; HAREFELL2; hepatic hyaluronan clearance receptor; Hyaluronan receptor for endocytosis; hyaluronic acid receptor for endocytosis; STAB2; Stabilin-2; Stabilin2
Gene Aliases: FEEL2; FELE-2; FELL; FELL2; FEX2; HARE; SCARH1; STAB2
UniProt ID: (Human) Q8WWQ8
Entrez Gene ID: (Human) 55576
Molecular Function: membrane trafficking regulatory protein