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      View (24) other STAT1 antibodies

      Invitrogen

      STAT1 Monoclonal Antibody (STAT1-79)

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      Antibody target was verified by IP Mass Spectrometry to ensure the antibody binds to the antigen stated. View details.

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      Catalog #:AHO0832

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      Product Details

      TESTED APPLICATIONS DILUTION
      ChIP assay (ChIP) 5µl
      Immunocytochemistry (ICC) 1:250
      Immunofluorescence (IF) 1:250
      Immunohistochemistry (Paraffin) (IHC (P)) 1:10-1:100
      Immunoprecipitation (IP) 0.5-1 µg/ml
      Western Blot (WB) 1:500
      PUBLISHED APPLICATIONS
      Western Blot (WB) See 1 publications below
      Tested Species reactivity Human, Mouse, Rat
      Published species reactivity Virus Human
      Host / Isotype Mouse / IgG1, kappa
      Class Monoclonal
      Type Antibody
      Clone STAT1-79
      Immunogen Recombinant human STAT1-alpha expressed in E. coli.
      Conjugate Unconjugated
      Form Liquid
      Purification purified
      Storage buffer PBS, pH 7.2, with 1% BSA
      Contains 0.1% sodium azide
      Storage conditions -20°C
      RRID AB_2536317

      Background/Target Information

      STAT1 (also known as signal transducers and activators of transcription) is a member of the STAT family of transcription factors. STAT proteins undergo phosphorylation in response to cytokines and growth factors and are translocated to the nucleus. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. The protein is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. The STAT1 gene is located on chromosome 2.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (1)

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      Bioinformatics

      Protein Aliases: signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT1; Transcription factor ISGF-3 components p91/p84

      Gene Aliases: 2010005J02Rik; AA408197; CANDF7; DD6G4-4; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91

      UniProt ID: (Human) P42224

      Entrez Gene ID: (Human) 6772, (Rat) 25124, (Mouse) 20846

      Molecular Function: nucleic acid binding transcription factor

      Function(s) Blue Arrow Icon
      negative regulation of transcription from RNA polymerase II promoter negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated apoptotic process JAK-STAT cascade blood circulation macrophage derived foam cell differentiation negative regulation of angiogenesis tumor necrosis factor-mediated signaling pathway response to cytokine response to interferon-beta cellular response to interferon-beta regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to peptide hormone endothelial cell migration positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation by virus of viral protein levels in host cell positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway renal tubule development cellular response to organic cyclic compound metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchymal cell differentiation negative regulation of metanephric nephron tubule epithelial cell differentiation cell-cell adhesion regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter activation of cysteine-type endopeptidase activity involved in apoptotic process response to nutrient positive regulation of cell proliferation response to mechanical stimulus response to bacterium response to organic cyclic compound cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide cellular response to insulin stimulus negative regulation of macrophage fusion response to drug response to hydrogen peroxide response to exogenous dsRNA cellular response to lipopolysaccharide signal transduction
      Process(es) Blue Arrow Icon
      RNA polymerase II core promoter proximal region sequence-specific DNA binding
       RNA polymerase II core promoter sequence-specific DNA binding
       transcription factor activity, RNA polymerase II core promoter sequence-specific
       double-stranded DNA binding
       transcription factor activity, sequence-specific DNA binding
       signal transducer activity
       tumor necrosis factor receptor binding
       protein binding
       enzyme binding
       nuclear hormone receptor binding
       identical protein binding
       protein homodimerization activity
       cadherin binding involved in cell-cell adhesion
       DNA binding
       CCR5 chemokine receptor binding
       sequence-specific DNA binding
       protein phosphatase 2A binding

      Suggested Secondary Antibodies

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