ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A.
ABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
STAT2 proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. STAT2, STAT1, and ISGF3G are involved in activating the transcription of IFN stimulated genes that triggers cellular resistance to viral infections. Cytoplasmic STAT2 is tyrosine phosphorylated by JAK kinase upon IFN engagement to IFN receptors, and translocated to the nucleus to act as a transcription factor. In humans, the gene is located on the q arm of the chromosome 12. Splicing variants produce two isoforms for human STAT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113
Gene Aliases: 1600010G07Rik; AW496480; IMD44; ISGF-3; P113; STAT113; STAT2
UniProt ID: (Human) P52630