The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
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Protein Aliases: OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; STAT4
Gene Aliases: SLEB11; STAT4
UniProt ID: (Human) Q14765
Entrez Gene ID: (Human) 6775