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STC1 Antibody (CF810025) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STC1 (RC206573, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-STC1. (1. Positive lysates LY401098 (100 µg) and LC401098 (20 µg) can be purchased separately from OriGene.
Product Details
CF810025
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI6D12
Immunogen
Human recombinant protein fragment corresponding to amino acids 34-247 of human STC1 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Stanniocalcin-1; STC-1
Gene Aliases: STC; STC1
UniProt ID: (Human) P52823, (Mouse) O55183, (Rat) P97574
Entrez Gene ID: (Human) 6781, (Dog) 486112, (Mouse) 20855, (Rat) 81801
ossification
endothelial cell morphogenesis
growth plate cartilage axis specification
cellular calcium ion homeostasis
embryo implantation
negative regulation of endothelial cell migration
negative regulation of cell migration
response to vitamin D
chondrocyte proliferation
regulation of anion transport
decidualization
negative regulation of calcium ion transport
bone development
cellular response to cAMP
cellular response to glucocorticoid stimulus
cellular response to hypoxia
regulation of cardiac muscle cell contraction
positive regulation of calcium ion import
negative regulation of renal phosphate excretion
cellular monovalent inorganic anion homeostasis
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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