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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 300-350 of human STRAD (isoform 1).|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Principal Names: LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524; Official Gene Symbol: LYK5 Gene ID: 92335 (Human) Gene Map Locus: 17q23.3 (Human) Members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
protein kinase LYK5; serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STRAD; STRAD alpha
LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA