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Invitrogen

STING Recombinant Rabbit Monoclonal Antibody (PSH07-44)

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STING Recombinant Rabbit Monoclonal Antibody (PSH07-44)

Product Details

MA562089

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:4,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:1,000
-

Immunoprecipitation (IP)

1-2 µg/sample
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH07-44

Immunogen

Recombinant protein within human STING aa 117-379.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3703083

Product Specific Information

Positive Control: HDLM-2 cell lysate, THP-1 cell lysate, HT-29 cell lysate, HepG2 cell lysate, HaCaT cell lysate, HL-60 cell lysate, HEK-293 cell lysate, K-562 cell lysate, A20 cell lysate, C2C12 cell lysate, EL4 cell lysate, Rat thymus tissue lysate, human lung tissue, human tonsil tissue, THP-1, PC-12.

Tissue Specificity: Low tissue specificity.

Subcellular Location: Endoplasmic reticulum membrane, Cytoplasm, perinuclear region, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Cytoplasmic vesicle, autophagosome membrane, Mitochondrion outer membrane, Cell membrane.

Sequence Similarities: 74%Mouse/Rat.

Predicted band size: 42 kDa.

Target Information

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; membrane protein; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; mSTING; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; rSTING; Stimulator of interferon genes protein; stimulator of interferon protein; stimulator of interferon response cGAMP interactor-deltaC; stimulator of interferon response cGAMP interactor-deltaN; sting 1; STING-deltaC; STING-deltaN; tm173; Transmembrane protein 173; transmembrane protein 173; TMEM173; unnamed protein product

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Gene Aliases: 2610307O08Rik; ERIS; hMITA; hSTING; MITA; MPYS; NET23; RGD1562552; SAVI; STING; STING-beta; STING1; TMEM173

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UniProt ID: (Human) Q86WV6, (Mouse) Q3TBT3, (Rat) F1M391

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Entrez Gene ID: (Human) 340061, (Mouse) 72512, (Rat) 498840

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Function(s)
nucleotide binding transcription coactivator activity protein binding hydrogen ion channel activity protein kinase binding ubiquitin protein ligase binding cyclic-di-GMP binding signaling adaptor activity identical protein binding protein homodimerization activity cyclic-GMP-AMP binding RNA polymerase II sequence-specific DNA binding transcription factor binding protein serine/threonine kinase binding transcription factor binding
Process(es)
autophagosome assembly activation of innate immune response pattern recognition receptor signaling pathway positive regulation of defense response to virus by host immune system process cytoplasmic pattern recognition receptor signaling pathway ion transport autophagy regulation of gene expression positive regulation of macroautophagy regulation of metabolic process signal transduction involved in regulation of gene expression positive regulation of type I interferon production protein exit from endoplasmic reticulum positive regulation of interferon-beta production ion transmembrane transport cellular response to interferon-beta innate immune response positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response protein oligomerization defense response to virus positive regulation of type I interferon-mediated signaling pathway reticulophagy protein localization to endoplasmic reticulum cellular response to exogenous dsRNA antiviral innate immune response cGAS/STING signaling pathway positive regulation of cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response hydrogen ion transmembrane transport apoptotic process positive regulation of protein binding interferon-beta production positive regulation of protein import into nucleus, translocation positive regulation of transcription factor import into nucleus
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