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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 16 amino acid peptide from internal region of human STX1A / Syntaxin 1A.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HPC-1; neuron-specific antigen HPC-1; p35-1; STX1; STX1A; SYN1a; Syntaxin 1A; Syntaxin 1A (brain)
HPC-1; P35-1; STX1; STX1A; SYN1A