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|Tested species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (121 KYPFREHLLQKKE 133) of SUCNR1/GPR91 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Western Blot (WB)||0.25-0.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
SUCNR1 is a 330 amino acid containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication. SUCNR1 a receptor for the citric acid cycle intermediate succinate, functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors including VEGF and may be involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases such as diabetic retinopathy that stem from aberrant neovascularization in the mature retina. Expression of SUCNR1 is common in kidney and in some other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
G protein-coupled receptor 91; G-protein coupled receptor 91; GPR91; P2Y purinoceptor 1