Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. SULT1C2 belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. SULT1C2 belongs to a SULT subfamily that shows specificity for hydroxyarylamines. SULT1C2 catalyzes the sulfonation of p-nitrophenol and N-hydroxy-2-acetylaminofluorene, but not dopamine.
Protein Aliases: 1C member 4; humSULTC2; MGC149521; MGC34422; ST1C2; Sulfotransferase 1C1; Sulfotransferase 1C2; sulfotransferase family, cytosolic, 1C, member 1; sulfotransferase family, cytosolic, 1C, member 2; SULT1C#1
Gene Aliases: humSULTC2; ST1C1; ST1C2; SULT1C1; SULT1C2
UniProt ID: (Human) O00338
Entrez Gene ID: (Human) 6819
Molecular Function: transferase