|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues A(6) K P S T E D L G D K K E G E Y(21) of human SUMO-1.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:2,000-1:4,000|
PA1-18267 detects SUMO1 from human and rat samples.
PA1-18267 has been successfully used in immunohistochemistry and Western blot procedures.
The PA1-18267 immunogen is a synthetic peptide corresponding to residues A(6) K P S T E D L G D K K E G E Y(21) of human SUMO-1, conjugated to diphtheria toxoid. The sequence is 100% conserved in rat.
Reconstitute with 100 ul of distilled water.
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.