|ChIP assay (ChIP)||Assay Dependent|
|Western Blot (WB)||1-3 ug/ml|
|Tested Species reactivity||Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (CKCGAVTCRGYLN) corresponding to the C-terminus amino acids of SUV39H2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, human, mouse and porcine based on sequence homology.
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ23414; histone-lysine N-methyltransferase SUV39H2; KMT1; KMT1B; RP11-2K17.2; suppressor of variation 3-9 (Drosophila) homolog 2 (Drosophila); suppressor of variegation 3-9 homolog 2; SUV39H2; uppressor of variegation 3-9 homolog 2 (Drosophila)
Entrez Gene ID: (Rat) 364785
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