Invitrogen

Sarcomeric alpha Actin Monoclonal Antibody (5C5)

Product Image Gallery

Sarcomeric alpha Actin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Sarcomeric alpha Actin in formalin-fixed, paraffin-embedded human skeletal muscle using a Sarcomeric alpha Actin monoclonal antibody (Product # MA1-21597).

Sarcomeric alpha Actin Antibody in Immunocytochemistry (ICC/IF) — Published figure using Sarcomeric alpha Actin monoclonal antibody (Product # MA1-21597) in Immunocytochemistry

Product Details

MA1-21597

Applications	Tested Dilution	Publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:25-1:50	-
Immunocytochemistry (ICC/IF)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human
Published species	Dog, Human
Host/Isotype	Mouse / IgM
Class	Monoclonal
Type	Antibody
Clone	5C5
Immunogen	Purified rabbit striated muscle allactin.
Conjugate	Unconjugated
Form	Liquid
Storage buffer	ascites
Contains	0.09% sodium azide
Storage conditions	4° C, do not freeze
RRID	AB_557425

Product Specific Information

MA1-21597 detects alpha sarcomeric actin in bovine, guinea pig,human, rabbit, rat, fish, pig, snake, Xenopus and sheep samples.

Target Information

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.

Nature biomedical engineering

Churko JM,Lee J,Ameen M,Gu M,Venkatasubramanian M,Diecke S,Sallam K,Im H,Wang G,Gold JD,Salomonis N,Snyder MP,Wu JC

MA1-21597 was used in Immunocytochemistry to find that the reprogramming method impacts the resulting transcriptome and that all hiPSC lines could terminally differentiate, regardless of the reprogramming method.

Sun Oct 01 00:00:00 EDT 2017

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.

Science translational medicine

Choi JC,Muchir A,Wu W,Iwata S,Homma S,Morrow JP,Worman HJ

Published figure using Sarcomeric alpha Actin monoclonal antibody (Product # MA1-21597) in Immunofluorescence

Wed Jul 25 00:00:00 EDT 2012

Valvular cardiac myxoma in a dog.

Journal of veterinary medicine. A, Physiology, pathology, clinical medicine

Akkoc A,Ozyigit MO,Cangul IT

MA1-21597 was used in immunohistochemistry to report on a case of valvular cardiac myxoma in a dog

Sat Sep 01 00:00:00 EDT 2007

ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor.

Genes, chromosomes & cancer

Debiec-Rychter M,Marynen P,Hagemeijer A,Pauwels P

MA1-21597 was used in immunohistochemistry to report molecular and clinicopathologic features of urinary bladder inflammatory myofibroblastic tumor

Wed Oct 01 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: act; actg; Actin, alpha cardiac muscle 1; Actin, alpha cardiac muscle 1, intermediate form; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; Actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; Alpha-actin-1; Alpha-actin-2; Alpha-cardiac actin; alpha-sma; beta-actin; Cell growth-inhibiting gene 46 protein; dfna20; dfna26; MGC75587; nemaline myopathy type 3

Gene Aliases: AAT6; ACTA; ACTA1; ACTA2; ACTC; ACTC1; ACTSA; ACTVS; ASD5; ASMA; CFTD; CFTD1; CFTDM; CMD1R; CMH11; GIG46; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; SHPM

UniProt ID: (Human) P68133, (Human) P62736, (Human) P68032

Entrez Gene ID: (Human) 58, (Human) 59, (Human) 70

Molecular Function: actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein