The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calcium-dependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer's disease. SAP is a decamer of 10 identical, noncovalently linked subunits, each of which may be posttranslationally modified by glycosylation.
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Protein Aliases: 9.5S alpha 1 glycoprotein; 9.5S alpha-1-glycoprotein; Amyloid P component serum; APCS; APCS amyloid P-component serum protein; epididymis secretory sperm binding protein Li 92n; MGC88159; Pentaxin related; pentaxin-related; Pentraxin 2; pentraxin-2; pentraxin-related; PTX 2; PTX2; SAMP; SAP; Serum amyloid P component; Serum amyloid P-component; Serum amyloid P-component(1-203)
Gene Aliases: APCS; HEL-S-92n; PTX2; SAP