In Western blots, 100% cross-reactivity with recombinant human (rh) Pentraxin 2 and 25% cross-reactivity with recombinant mouse (rm) Pentraxin 2 is observed. In direct ELISAs, no cross-reactivity with rhPentraxin 2 or rmPentraxin 2 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: pentaxin-related; PTX2; SAP; Serum amyloid P-component
Gene Aliases: Apcs; Ptx2; Sap
UniProt ID: (Rat) P23680
Entrez Gene ID: (Rat) 29339