|Western Blot (WB)||2-4 µg/ml|
|Tested Species reactivity||Bovine, Dog, Horse, Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A portion of amino acids 40-90 of human Siglec9 was used as the immunogen|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Siglec9 (Sialic acid-binding Ig-like lectin 9) is single-pass type I membrane protein and belongs to immunoglobulin super family and contains two Ig-like C2 type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is reported that Siglec9 recognizes sialic acid in alpha2, 3-or alpha2, 6-glycosidic linkage to galactose. Using a specific antibody, Siglec9 was found to be expressed at high or intermediate levels by monocytes, neutrophils, and a minor population of CD16+, CD56- cells. Siglec9 also acts as an inhibitory receptor for MUC16 that attenuates T- and NK cell function. Recent reports suggest that Siglec9 expressed on DCs is involved in immuno regulation through ligation with mucins in an epithelial cancer patient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD329; CDw329; FOAP-9; OBBP-LIKE; Protein FOAP-9; sialic acid binding Ig-like lectin 9; Sialic acid-binding Ig-like lectin 9; Siglec-9; UNQ668/PRO1302
Gene Aliases: CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9; SIGLEC9; UNQ668/PRO1302
UniProt ID: (Human) Q9Y336
Entrez Gene ID: (Human) 27180
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule membrane-bound signaling molecule myelin protein receptor signaling molecule structural protein
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