Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
- | View 1 publication 1 publication |
Immunohistochemistry (IHC) |
- | View 5 publications 5 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200-1:400 | - |
Immunocytochemistry (ICC/IF) |
2 µg/mL | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Amphibian, Bovine, Guinea pig, Human, Mouse, Sheep, Rabbit, Rat |
Published species |
Human, Mouse, Rabbit |
Host/Isotype |
Mouse / IgM, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
5C5.F8.C7 (alpha-Sr-1) |
Immunogen |
N-terminal decapeptide |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Ammonium sulfate precipitation |
Storage buffer |
PBS, pH 7.4, with 0.2% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
RRID |
AB_10984949 |
MA5-12542 targets Actin Skeletal Muscle in IF and IHC (P) applications and shows reactivity with Amphibian, Bovine, Guinea Pig, Human, Ovine, Rabbit, and Rat samples.
The MA5-12542 immunogen is n-terminal decapeptide.
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: actin alpha 1; actin, alpha 2, smooth muscle, aorta; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; alpha actin; alpha actin 2; Alpha-actin-1; Alpha-actin-2; alpha-cardiac actin; alpha-smooth muscle actin; Cell growth-inhibiting gene 46 protein; cytoplasmic beta-actin; nemaline myopathy type 3; smooth muscle alpha-actin; unnamed protein product
Gene Aliases: 0610041G09Rik; a-SMA; AA959943; AAT6; ACTA; Acta-2; ACTA1; ACTA2; Acts; ACTSA; Actsk-1; ACTVS; alphaSMA; ASMA; CFTD; CFTD1; CFTDM; GIG46; MPFD; MYMY5; NEM1; NEM2; NEM3; SHPM; SMalphaA
UniProt ID: (Human) P68133, (Bovine) P68138, (Rabbit) P62740, (Bovine) P62739, (Human) P62736, (Mouse) P68134, (Rat) P68136, (Rat) P62738, (Mouse) P62737
Entrez Gene ID: (Human) 58, (Bovine) 281592, (Rabbit) 100009506, (Sheep) 101107662, (Rabbit) 100009271, (Bovine) 515610, (Human) 59, (Sheep) 101121051, (Guinea pig) 100716933, (Mouse) 11459, (Rat) 29437, (Rat) 81633, (Mouse) 11475, (Guinea pig) 100722917
Molecular Function:
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
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