The Slo3 channel is a novel potassium channel abundantly expressed in mammalian speramtocytes- tests have shown that it is expressed in both mouse and human testis. It represents a new and unique type of potassium channel that is regulated by both intracellular pH and membrane voltage. Because of its sensitivity to both pH and voltage, Slo3 may play a role in alkalization-mediated K(+) fluxes associated with sperm capacitation.
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Protein Aliases: Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; KCa5; KSper; mSlo3; pH-sensitive maxi potassium channel; Pore-forming subunit of the sperm-specific alkalization activated K(+) current; Potassium channel subfamily U member 1; potassium channel, subfamily U, member 1; potassium large conductance pH-sensitive channel, subfamily M, alpha member 3; Slowpoke homolog 3
Gene Aliases: KCa5; KCa5.1; KCNMA3; KCNMC1; KCNU1; Ksper; mSlo3; SLO3
Molecular Function: ion channel