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|Tested species reactivity||Bovine, Human, Mouse, Primate, Rabbit, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Synthetic peptide corresponding to the N-terminal residues M(1) C E E E D S T A L(10) of alpha smooth muscle Actin.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||0.5-1 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA1-26017 detects alpha smooth muscle Actin from human, mouse, rat, rabbit, bovine, baboon samples. It does not react with fibroblasts, striated muscle, or myocardium.
MA1-26017 has been successfully used in immunohistochemistry (paraffin/frozen), and Immunoflourescence procedures. Positive control of smooth muscle or leiomyosarcoma suggested.
The MA1-26017 immunogen is a synthetic peptide corresponding to the N-terminal residues M(1) C E E E D S T A L(10) of alpha smooth muscle Actin.
Store at 4°C short term. For extended storage, store at -20°C, avoiding freeze/thaw cycles.
Stains smooth muscle cells in vessel walls, gut walls, and myometrium. Myoepithelial cells in breat and salivary gland are also stained. This antibody reacts with tumors arising from smooth muscles and myoepithlial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.
MA1-26017 was used in western blot to study the role of Src homology phosphotyrosyl phosphatase 2 (SHP2) in triple negative breast cancers
|Zhao H,Agazie YM||BMC cancer (15:null)||2015|
AAT6; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; ACTSA; alpha actin 2; alpha-actin-2; alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; cell growth-inhibiting gene 46 protein; smooth muscle alpha-actin
0610041G09Rik; a-SMA; AAT6; ACTA2; ACTSA; ACTVS; alphaSMA; BOS_23286; GIG46; MYMY5; SMalphaA