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|Tested species reactivity||Chicken, Human, Rat|
|Published species reactivity||Rabbit, Rat, Pig, Cat, Mouse, Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Synthetic peptide derived from the N-terminus of smooth muscle actin|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunohistochemistry (IHC)||1:1000 - 1:10000|
|Immunomicroscopy (IM)||Assay Dependent|
|Western Blot (WB)||1:10000 - 1:50000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
MA1-12772 was used in immunohistochemistry to study the time-course of extracellular matrix deposition and dermal fibrogenesis in the murine Tsk2 model of systemic sclerosis
|Long KB,Artlett CM,Blankenhorn EP||Matrix biology : journal of the International Society for Matrix Biology (38:91)||2014|
Dynamic intersection of the longitudinal muscle and external anal sphincter in the layered structure of the anal canal posterior wall.
MA1-12772 was used in immunohistochemistry to study the detailed structure of the posterior anal canal
|Muro S,Yamaguchi K,Nakajima Y,Watanabe K,Harada M,Nimura A,Akita K||Surgical and radiologic anatomy : SRA (36:551)||2014|
Use of platelet-rich plasma solution applied with composite chondrocutaneous graft technique: an experimental study in rabbit model.
MA1-12772 was used in immunohistochemistry to study the mechanisms underlying the beneficial effects of using platelet-rich plasma in composite chondrocutaneous graft procedures
|Sevim KZ,Yazar M,Irmak F,Tekkeşin MS,Yildiz K,Sirvan SS||Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (72:1407)||2014|
Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine.
MA1-12772 was used in immunohistochemistry to study the implications for tissue engineering and regenerative medicine of the identification of a population of human adipose tissue stem cells with low telomerase that lack teratogenic activity
|Ogura F,Wakao S,Kuroda Y,Tsuchiyama K,Bagheri M,Heneidi S,Chazenbalk G,Aiba S,Dezawa M||Stem cells and development (23:717)||2014|
Diet induced mild hypercholesterolemia in pigs: local and systemic inflammation, effects on vascular injury - rescue by high-dose statin treatment.
MA1-12772 was used in immunohistochemistry to study the effects of high-dose statin therapy on inflammation and vascular injury in a porcine model of mild hypercholesterolemia
|Busnelli M,Manzini S,Froio A,Vargiolu A,Cerrito MG,Smolenski RT,Giunti M,Cinti A,Zannoni A,Leone BE,Forni M,Bacci ML,Biasi GM,Giovannoni R,Lavitrano M||PloS one (8:null)||2013|
DNA microarray and quantitative analysis reveal enhanced myocardial VEGF expression with stunted angiogenesis in human tetralogy of Fallot.
MA1-12772 was used in immunohistochemistry to study the role of elevated myocardial expression of VEGF in the pathology of human tetralogy of Fallot
|Peters TH,Sharma V,Yilmaz E,Mooi WJ,Bogers AJ,Sharma HS||Cell biochemistry and biophysics (67:305)||2013|
Keratocyte apoptosis and not myofibroblast differentiation mark the graft/host interface at early time-points post-DSAEK in a cat model.
MA1-12772 was used in immunohistochemistry to study keratinocyte apoptosis as a graft-host marker in a feline model of Descemet's stripping automated endothelial keratoplasty
|Weis AJ,Huxlin KR,Callan CL,DeMagistris MA,Hindman HB||PloS one (8:null)||2013|
Protective effect of Urtica dioica on liver damage induced by biliary obstruction in rats.
MA1-12772 was used in immunohistochemistry to study the ability of Urtica dioica to protect against liver damage in a rat bile duct ligation model
|Oguz S,Kanter M,Erboga M,Ibis C||Toxicology and industrial health (29:838)||2013|
Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review.
MA1-12772 was used in immunohistochemistry to develop a hypothesis of Kaposi sarcoma histogenesis based on a case and literature review
|Gurzu S,Ciortea D,Munteanu T,Kezdi-Zaharia I,Jung I||PloS one (8:null)||2013|
The effect of platelet-rich plasma on flap survival in random extension of an axial pattern flap in rabbits.
MA1-12772 was used in immunohistochemistry to study the mechanisms underlying the beneficial effects of autologous platelet-rich plasma on axial pattern flap procedures in a rabbit model
|Kim HY,Park JH,Han YS,Kim H||Plastic and reconstructive surgery (132:85)||2013|
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
MA1-12772 was used in immunohistochemistry to report on two cases of malignant transformation of adenomyoepithelioma of the breast by a monophasic population
|Marian C,Boila A,Soanca D,Malau M,Podeanu DM,Resetkova E,Stolnicu S||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (121:272)||2013|
Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats.
MA1-12772 was used in immunohistochemistry to study the beneficial effects in a rat model of nephritis of therapy with bone marrow-derived mesenchymal stem cells
|Sakr S,Rashed L,Zarouk W,El-Shamy R||Asian Pacific journal of tropical biomedicine (3:174)||2013|
Thy-1 knockdown retards wound repair in mouse skin.
MA1-12772 was used in immunohistochemistry to study the role of Thy-1 in the repair of murine skin wounds using siRNA-mediated knockdown
|Lee MJ,Shin JO,Jung HS||Journal of dermatological science (69:95)||2013|
Cyclic adenosine monophosphate response-element binding protein activation by mitogen-activated protein kinase-activated protein kinase 3 and four-and-a-half LIM domains 5 plays a key role for vein graft intimal hyperplasia.
MA1-12772 was used in immunohistochemistry to study the intimal hyperplasia of vein grafts and the roles played by CREB, MAPKAPK3 and FHL5
|Nakanishi K,Saito Y,Azuma N,Sasajima T||Journal of vascular surgery (57:182)||2013|
Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia.
MA1-12772 was used in immunohistochemistry to study the role of SEMA3-neuropilin-1 signaling in the vascular development of the fetal lung and the effects of signaling deficiency
|Joza S,Wang J,Fox E,Hillman V,Ackerley C,Post M||The American journal of pathology (181:2003)||2012|
Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice.
MA1-12772 was used in immunohistochemistry to study the ability of an orally administered recombinant AAV-BMP-7 virus to protect against experimentally induced hepatic fibrosis in a murine model
|Hao ZM,Cai M,Lv YF,Huang YH,Li HH||Molecular therapy : the journal of the American Society of Gene Therapy (20:2043)||2012|
Multipotent nestin-expressing stem cells capable of forming neurons are located in the upper, middle and lower part of the vibrissa hair follicle.
MA1-12772 was used in immunohistochemistry to study hair follicle multipotent stem cells that express nestin and are capable of differentiating into neurons
|Amoh Y,Mii S,Aki R,Hamada Y,Kawahara K,Hoffman RM,Katsuoka K||Cell cycle (Georgetown, Tex.) (11:3513)||2012|
Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung.
MA1-12772 was used in immunohistochemistry to study the role of LTBP-1 in modulating TGF-beta levels in the lungs of patients with idiopathic pulmonary fibrosis
|Leppäranta O,Sens C,Salmenkivi K,Kinnula VL,Keski-Oja J,Myllärniemi M,Koli K||Cell and tissue research (348:491)||2012|
Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats.
MA1-12772 was used in immunohistochemistry to study the mechanisms underlying the protective and therapeutic effects of thymoquinone in a rat model of cholestatic liver disease
|Oguz S,Kanter M,Erboga M,Erenoglu C||Journal of molecular histology (43:151)||2012|
The pulmonary mesenchymal tissue layer is defective in an in vitro recombinant model of nitrofen-induced lung hypoplasia.
MA1-12772 was used in immunohistochemistry to develop a recombinant in vitro cellular model of lung hypoplasia
|van Loenhout RB,Tseu I,Fox EK,Huang Z,Tibboel D,Post M,Keijzer R||The American journal of pathology (180:48)||2012|
Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast.
MA1-12772 was used in immunohistochemistry to study the serum angiogenic factor profile of women with complete placenta previa
|Wehrum MJ,Buhimschi IA,Salafia C,Thung S,Bahtiyar MO,Werner EF,Campbell KH,Laky C,Sfakianaki AK,Zhao G,Funai EF,Buhimschi CS||American journal of obstetrics and gynecology (204:411.e1)||2011|
Myometrial wound healing post-Cesarean delivery in the MRL/MpJ mouse model of uterine scarring.
MA1-12772 was used in immunohistochemistry to investigate myometrial wound healing process after cesarean delivery
|Buhimschi CS,Zhao G,Sora N,Madri JA,Buhimschi IA||The American journal of pathology (177:197)||2010|
Chick pulmonary Wnt5a directs airway and vascular tubulogenesis.
MA1-12772 was used in immunohistochemistry to study the role of non-cannonical Wnt5a in modulating pulmonary airway and vascular tubulogenesis
|Loscertales M,Mikels AJ,Hu JK,Donahoe PK,Roberts DJ||Development (Cambridge, England) (135:1365)||2008|
Epithelioid leiomyosarcoma with rhabdoid features.
MA1-12772 was used in immunohistochemistry to report on a case of epithelioid leiomyosarcoma with rhabdoid features
|Yorulmaz G,Erdogan G,Pestereli HE,Savas B,Karaveli FS||Wiener klinische Wochenschrift (119:557)||2007|
Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering.
MA1-12772 was used in immunohistochemistry to study the ability of angiotensin receptor blockers to protect against kidney damage independently of blood pressure lowering effects
|Izuhara Y,Nangaku M,Inagi R,Tominaga N,Aizawa T,Kurokawa K,van Ypersele de Strihou C,Miyata T||Journal of the American Society of Nephrology : JASN (16:3631)||2005|
Synchronous primary adenocarcinoma and gastrointestinal stromal tumor in the stomach: a report of two cases.
MA1-12772 was used in immunohistochemistry to report on two patients with synchronous primary adenocarcinoma and gastrointestinal stromal tumor in the stomach
|Bircan S,Candir O,Aydin S,Başpinar S,Bülbül M,Kapucuoğlu N,Karahan N,Ciriş M||The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (15:187)||2004|
Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats.
MA1-12772 was used in immunohistochemistry to study the potential mechanisms by which gonko biloba extract reverses CCl4-induced liver injury in a mouse model
|Luo YJ,Yu JP,Shi ZH,Wang L||World journal of gastroenterology (10:1037)||2004|
Human pathological basis of blood vessels and stromal tissue for nanotechnology.
MA1-12772 was used in immunocytochemistry to review the pathophysiology of nanotechnology
|Nishihara H||Advanced drug delivery reviews (74:19)||2014|
Stromal-epithelial crosstalk provides a suitable microenvironment for the progression of ovarian cancer cells in vitro.
MA1-12772 was used in immunocytochemistry to study the in vivo progression of ovarian cancer cells and the role of stromal-epithelial interactions in creating an appropriate microenvironment
|Fu S,Dong L,Sun W,Xu Y,Gao L,Miao Y||Cancer investigation (31:616)||2013|
Fstl1 antagonizes BMP signaling and regulates ureter development.
MA1-12772 was used in immunocytochemistry to study the antagonization of BMP signaling by Fstl1 and the significance for normal development of the ureter
|Xu J,Qi X,Gong J,Yu M,Zhang F,Sha H,Gao X||PloS one (7:null)||2012|
Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture.
MA1-12772 was used in immunocytochemistry to study which factors are involved in postnatal lacrimal gland development
|Ueda Y,Karasawa Y,Satoh Y,Nishikawa S,Imaki J,Ito M||Investigative ophthalmology & visual science (50:1978)||2009|
Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1.
MA1-12772 was used in western blot to study the ability of vaccination against TGF-beta1 to protect against hepatic fibrosis in a liver injury model
|Fan X,Zhang Q,Li S,Lv Y,Su H,Jiang H,Hao Z||PloS one (8:null)||2013|
Vaccination with platelet-derived growth factor B kinoids inhibits CCl₄-induced hepatic fibrosis in mice.
MA1-12772 was used in western blot to study the ability of vaccination against PDGF-D to protect against hepatic fibrosis in a rat model of acute liver injury
|Hao ZM,Fan XB,Li S,Lv YF,Su HQ,Jiang HP,Li HH||The Journal of pharmacology and experimental therapeutics (342:835)||2012|
Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling.
MA1-12772 was used in western blot to study the role of MAPK/Erk signaling in the mechanism by which asbestos exposure induces plasticity in alveolar epithelial cells
|Tamminen JA,Myllärniemi M,Hyytiäinen M,Keski-Oja J,Koli K||Journal of cellular biochemistry (113:2234)||2012|
a-SM1; actin, aortic smooth muscle; alpha-actin; alpha-actin-2; alpha-cardiac actin; alpha-sma; cell growth-inhibiting gene 46 protein; smooth muscle alpha-actin
AAT6; ACTA2; ACTSA; ACTVS; asma; GIG46; MYMY5