TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
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Protein Aliases: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SNO, SnoA, SnoI, SnoN
Gene Aliases: SKIL; SNO; SnoA; SnoI; SnoN
UniProt ID: (Human) P12757
Entrez Gene ID: (Human) 6498