|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (135 ANGDIFDIEIGVSDPEKV 152) of Snx2 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.25-0.50 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Snx2 is a signaling protein belonging to the sorting nexin family and characterized by the presence of a 100 amino acid region known as the phox (PX) homology domain (a phosphoinositide binding domain). As a transport carrier SNX2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway. The retromer complex that is composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2, is required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Though Snx2 associates with formin-binding protein 17, its function is yet unknown. It may form oligomeric complexes with itself as well as with other family members Snx1, Snx1A, and Snx4, but not with Snx3 and is ubiquitously expressed in most tissues, including peripheral leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.