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Recommended positive controls: A549, IMR32.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: clone iota unknown protein; hCG_23393; OTTHUMP00000035515; Sorting nexin-15
Gene Aliases: HSAF001435; SNX15
UniProt ID: (Human) Q9NRS6
Entrez Gene ID: (Human) 29907
Molecular Function: non-receptor serine/threonine protein kinase
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