Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart. Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier.
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Protein Aliases: Beta-IV spectrin; beta-spectrin 4; BetaIV-spectrin sigma1; EMBL BAB83243.1; Ensembl ENSRNOP00000028393; KIAA1642; lumbosacral neuroaxonal dystrophy; neuroaxonal dystrophy; Non-erythrocytic spectrin beta chain 4; Non-erythroidspectrin beta chain 3; quivering; spectrin beta 4; spectrin beta chain, brain 3; Spectrin beta chain, non-erythrocytic 4; spectrin, beta, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3; Spnb4; SPTBN3; SPTBN4
Gene Aliases: 1700022P15Rik; 5830426A08Rik; dyn; KIAA1642; lnd; nmf261; nmf379; QV; ROSA62; SpbIV; SPNB4; SPTBN3; SPTBN4
UniProt ID: (Human) Q9H254