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|Tested species reactivity||Bovine, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to sphingosine 1-phosphate lyase 1.|
|Purification||Antigen affinity chromatography|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:400|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
By Western blot, PA1-12722 detects a ~64 kDa protein representing S1P lyase 1 from MDBK cell lysate.
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AI428538; D10Xrf456; hSPL; mSPL; SP-lyase 1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase; sphingosine-1-phosphate lyase 1; Spl; SPL 1
AI428538; BOS_24203; D10Xrf456; KIAA1252; S1PL; SGPL1; Spgl1; SPL