|Tested species reactivity||Mouse|
|Host / Isotype||unidentified baculovirus|
|Storage buffer||TBS, pH 8.0, with 50% glycerol, 3mM DTT, 0.05% Tween 20|
|Storage Conditions||-80° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Sphingolipids have emerged as central signaling molecules regulating a variety of fundamental cell responses such as cell death and differentiation, proliferation and inflammation. Ceramide has been a main focus of research since it possesses pro-apoptotic capacity in many cell types. Sphingosine-1-phosphate (S1P), which is generated from ceramide by the actions of ceramidase and sphingosine kinase can potently induce cell proliferation via binding to and activation of the S1P family of receptors. The balance between ceramide and sphingosine-1-phosphate determines whether cells undergo apoptosis or proliferate, two cell responses that are critically involved in tumor development. The amino acid sequence for sphingosine kionase 1a differs from sphingosine kinase 1 only in the absence of a valine at position 4 of sphingosine kinase 1a.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.