|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminus of survivin|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:250-1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16534 targets Survivin in IHC (P) applications and shows reactivity with mouse and Human samples.
The PA5-16534 immunogen is a synthetic peptide derived from the C-terminus of survivin.
Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Significance of intracellular localization of survivin in cervical squamous cell lesions: Correlation with disease progression.
PA5-16534 was used in immunohistochemistry to study the role and prognostic significance of survivin intracellular localization in patients with cervical squamous cell lesions
|Kim SA,Hong R||Oncology letters (7:1589)||2014|
Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in head and neck squamous cell carcinoma patients.
PA5-16534 was used in immunohistochemistry to study the prognostic and clinical value of survivin expression levels in patients with head and neck squamous cell carcinoma
|Farnebo L,Tiefenböck K,Ansell A,Thunell LK,Garvin S,Roberg K||International journal of cancer (133:1994)||2013|
ERCC1 Can Be a Prognostic Factor in Hilar Cholangiocarcinoma and Extrahepatic Bile Duct Cancer, But Not in Intrahepatic Cholangiocarcinoma.
PA5-16534 was used in immunohistochemistry to study the differential prognostic value of the immunohistochemical expression of ERCC1 in the three types of bile duct cancer
|Park KW,Jung ES,Kim DG,Yoo YK,Hong TH,Lee IS,Koh YH,Kim JH,Lee MA||Cancer research and treatment : official journal of Korean Cancer Association (45:63)||2013|
Prognostic significance of Bcl-2, tumor-associated macrophages, and total neoplastic and inflammatory lymph node involvement in advanced stage classical Hodgkin's lymphoma.
PA5-16534 was used in immunohistochemistry to study the prognostic value of a range of parameters in patients with classical Hodgkin's lymphoma
|Jakovic LR,Mihaljevic BS,Jovanovic MD,Bogdanovic AD,Andjelic BM,Bumbasirevic VZ||Onkologie (35:733)||2012|
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
PA5-16534 was used in immunohistochemistry to study the influence of the phenotype of apoptosis-associated proteins on the clinical significance of cathepsin D expression in non-small cell lung cancer
|Fan C,Lin X,Wang E||Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (33:1045)||2012|
Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer.
PA5-16534 was used in immunohistochemistry to investigate the prognostic value of survivin expression in stage III non-small cell lung cancer
|Wang M,Liu BG,Yang ZY,Hong X,Chen GY||Experimental and therapeutic medicine (3:983)||2012|
Expression profiles of p63, p53, survivin, and hTERT in skin tumors.
PA5-16534 was used in immunohistochemistry - paraffin section to study the expression of p63, p53, survivin, and hTERT in skin tumors
|Park HR,Min SK,Cho HD,Kim KH,Shin HS,Park YE||Journal of cutaneous pathology (31:544)||2004|