This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control for this product is THP-1 cells.
Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcgamma receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.
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Protein Aliases: p72-Syk; Spleen tyrosine kinase; Tyrosine-protein kinase SYK
Gene Aliases: p72-Syk; SYK
UniProt ID: (Human) P43405
Entrez Gene ID: (Human) 6850