Immunogen sequence: HGQYSILQTA RLLPGAPQQP PKARTGISKP YNVKQIKTTN AQEAEAAIRC LLEARGGASE EALSAVAPRD LEASSEP
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: inositol phosphate 5'-phosphatase 2; inositol polyphosphate-5-phosphatase H; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2; Synaptojanin-2
Gene Aliases: AI481647; INPP5H; KIAA0348; mKIAA0348; SJ2; SYNJ2
Molecular Function: phosphatase