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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a conjugated to KLH.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-18270 detects Synphilin-1 from human and rat samples.
PA1-18270 has been successfully used in immunohistochemistry and Western blot procedures.
The PA1-18270 immunogen is a synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a, conjugated to KLH.
After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Reconstitute with 100 ul of distilled water. Centrifuge to remove any insoluble material.
Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
SNCAIP; synphilin-1; synuclein, alpha interacting protein; synuclein, alpha interacting protein (synphilin)
SNCAIP; Sph1; SYPH1