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Syntaxin 1a (STX1A) Antibody (TA812825) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STX1A (RC209062, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STX1A (1:500).
Product Details
TA812825
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1D8
Immunogen
Full length human recombinant protein of human STX1A (NP_004594) produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neuron-specific antigen HPC-1; P35A; STX1B; STX1B1; STX1B2; STXA1; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A
Gene Aliases: HPC-1; P35-1; Sap; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623, (Mouse) O35526, (Rat) P32851
Entrez Gene ID: (Human) 6804, (Mouse) 20907, (Rat) 116470
SNARE binding
glycoprotein binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein domain specific binding
protein binding, bridging
myosin head/neck binding
ATP-dependent protein binding
ion channel binding
protein heterodimerization activity
protein N-terminus binding
calcium-dependent protein binding
SNARE protein
positive regulation of neurotransmitter secretion
intracellular protein transport
neurotransmitter secretion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle fusion to presynaptic active zone membrane
secretion by cell
positive regulation of catecholamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
regulation of insulin secretion
positive regulation of excitatory postsynaptic potential
transport
neurotransmitter transport
exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
positive regulation of exocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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