The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; ST1; SYCL; syndecan binding protein (syntenin); Syndecan-binding protein 1; Syntenin-1; TACIP18
Gene Aliases: MDA-9; MDA9; SDCBP; ST1; SYCL; TACIP18
UniProt ID: (Human) O00560
Entrez Gene ID: (Human) 6386